医学
肾脏疾病
队列
肾病科
内科学
疾病
肾功能
队列研究
人口
心脏病学
环境卫生
作者
Carl P. Walther,Sankar D. Navaneethan
标识
DOI:10.1016/j.kint.2023.02.020
摘要
Japanese and US populations have similar chronic kidney disease prevalence but differing clinical outcomes. A secondary analysis compared cardiovascular outcomes in a Japanese- and a US-based chronic kidney disease cohort and found that the US cohort had markedly worse cardiovascular outcomes. Mediation analysis demonstrated that differences in left ventricular structure and function could explain most of the cardiovascular outcome difference. We examine and contextualize this finding and describe implications for precision nephrology and for population health.
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