生发中心
体细胞突变
抗体
生物
人性化鼠标
病毒学
B细胞
免疫球蛋白类转换
免疫学
免疫系统
作者
Daniel P. Chupp,Carlos Eduardo Rivera,Yulai Zhou,Yijiang Xu,Patrick S. Ramsey,Zhenming Xu,Hong Zan,Paolo Casali
标识
DOI：10.1038/s41590-024-01880-3
摘要
Humanized mice are limited in terms of modeling human immunity, particularly with regards to antibody responses. Here we constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated Kit
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