Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C-H Bonds Using Iridium Catalysis

Reported here is the iridium-catalyzed regio- and enantio-selective secondary benzylic C-H borylation using benzothiazole as the directing group. Various monosubstituted 2-arylalkylbenzo[d]thiazole were well-tolerated, affording corresponding products in moderate to good yields with good enantioselectivity. The C-B bond in one borylated product could undergo stereospecific transformations to form a series of C-C and C-heteroatom bonds.