吞噬作用
铜绿假单胞菌
巨噬细胞
微生物学
组分(热力学)
生物
化学
细胞生物学
细菌
遗传学
体外
物理
热力学
作者
Xiaolong Guo,Hua Yu,Junzhi Xiong,Qian Dai,Yuanyuan Li,Caiqing Zhang,Xiaoyun Liao,Xiaomei He,Hongli Zhou,Kebin Zhang
出处
期刊:MBio
[American Society for Microbiology]
日期:2024-05-21
卷期号:15 (6)
被引量:1
标识
DOI:10.1128/mbio.00616-24
摘要
is one of the most common nosocomial pathogens worldwide, known for its virulence, drug resistance, and elaborate sensor-response network. The primary challenge encountered by pathogens during the initial stages of infection is the immune clearance arising from the host. The resident macrophages of barrier organs serve as the frontline defense against these pathogens. Central to our understanding is the mechanism by which bacteria modify their behavior to circumvent macrophage-mediated clearance, ensuring their persistence and colonization. To successfully evade macrophage-mediated phagocytosis, bacteria must possess an adaptive response mechanism. Two-component systems provide bacteria the agility to navigate diverse environmental challenges, translating external stimuli into cellular adaptive responses. Here, we report that the well-documented histidine kinase, LadS, coupled to a cognate two-component response regulator, PA0034, governs the expression of a vital adhesin called chaperone-usher pathway pilus cupA. The LadS/PA0034 system is susceptible to interference from the reactive oxygen species likely to be produced by macrophages and further lead to a poor adhesive phenotype with scantily cupA pilus, impairing the phagocytosis efficiency of macrophages during acute infection. This dynamic underscores the intriguing interplay: as macrophages deploy reactive oxygen species to combat bacterial invasion, the bacteria recalibrate their exterior to elude these defenses.
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