Effectiveness, adherence and safety of home high flow nasal cannula in chronic respiratory disease and respiratory insufficiency: a systematic review

医学 支气管扩张 鼻插管 慢性阻塞性肺病 随机对照试验 重症监护医学 生活质量(医疗保健) 呼吸系统 物理疗法 内科学 套管 外科 护理部
作者
Cristina Jácome,Marta Jácome,Sara Correia,Inês Flores,Patrícia Farinha,Mónica López Duarte,João Carlos Winck,Javier Sayas Catalán,Salvador Díaz Lobato,Manel Luján,Cátia Caneiras
出处
期刊:Archivos De Bronconeumologia [Elsevier]
标识
DOI:10.1016/j.arbres.2024.05.001
摘要

Introduction: The effectiveness of home high flow nasal cannula (HFNC) for the treatment of chronic respiratory failure in patients with chronic respiratory diseases (CRDs) has not been summarized. We aimed to conduct a systematic review of the effectiveness, adherence, and safety of HFNC in the long-term treatment of patients with chronic respiratory diseases and respiratory failure. Methods: A systematic review was conducted. PubMed, Web of science, and SCOPUS were search up to August 2023. Long-term HFNC studies (≥4 weeks) reporting dyspnea; exacerbations, hospitalizations; peripheral oxygen saturation (SpO2), comfort; patient experience, health-related quality of life or partial pressure of carbon dioxide (paCO2) were included. Results: Thirteen articles (701 patients) based on 10 studies were selected: randomized control trials (n=3), randomized crossover trials (n=2), crossover (n=3) and retrospective (n=2) studies. COPD (n=6), bronchiectasis (n=2), COPD/bronchiectasis (n=1) and ILD (n=1) were the underlined CRDs. HFNC reduced exacerbations when compared to usual care/home respiratory therapies (n=6). Quality of life outcomes were also in favor of HFNC in patients with COPD and bronchiectasis (n=6). HFNC had significant effects on hospitalizations, paCO2, and lung function. Adherence ranged from 5.2-8.6h/day (n=5). Three studies reported no events, 3 non-serious events and 2 no differences compared with other home respiratory therapies. Conclusions: HFNC seems more effective than usual care or other home respiratory therapies in reducing exacerbations and improving quality of life in patients with COPD and bronchiectasis, while presenting good adherence and being safe. Its apparently superior effectiveness needs to be better studied in future real-world pragmatic trials.

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