Photoactivation of cGAS-STING Pathway and Pyroptosis by Endoplasmic Reticulum-Targeting Ruthenium(II) Complex for Cancer Immunotherapy

Three multifunctional ruthenium(II) complexes (Ru1-Ru3) modified with cholic acid, were synthesized, which possessed excellent singlet oxygen-generating ability and near-infrared (NIR) aggregation-induced emission (AIE) phosphorescence activity. Cellular toxicity assays revealed that...