Modification of Azo-Aminopyrimidines as Potent Multitarget Inhibitors of Insect Chitinolytic Enzymes OfChi-h and OfHex1

Multitarget inhibitors exhibit significant advantages in reducing the risk of drug resistance, enhancing therapeutic efficacy, and minimizing dosage, outperforming multicomponent combination drugs. On the basis of glycoside hydrolase family 18 (GH18) chitinases and GH20 β-