Synthesis and antiproliferative activities of 2,3,5-trisubstituted 1H-pyrroles via formal [3+2] cycloaddition of 1-arylpropynes and nitriles

A straightforward approach for the assemble of 2,3,5-trisubstituted 1H-pyrroles via a base-mediated [3+2] cycloaddition of 1-arylpropynes with nitriles has been reported through the alkali metal salts promoted C(sp3)-H functionalization. This...