An overview of palladium-catalyzed trifluoromethylation reactions

• Examples of trifluoromethylation reactions which exhibit broad functional group tolerance and excellent yields. • Understanding the crucial role of palladium catalysts in trifluoromethylation reactions based on the reaction mechanisms. • The use of diverse palladium catalysts such as Pd(OAc)2, Pd(PPh3)2Cl2 and Pd2(dba)3. • Salient features of palladium catalyst like high reaction rates, selectivity, yields, higher activity, higher performance at relatively lower temperatures and high catalyst turnover numbers which helps in the increased efficiency of the reaction. C-CF 3 bond and its methods of formation could gather great attention in the area of organofluorine chemistry because of its applications in various fields like pharmaceuticals, material science and agrochemicals. Several palladium-catalyzed trifluoromethylation reactions could be developed in the last decade. Broad functional group tolerance and good selectivity make palladium catalysts extremely useful in industrial manufacturing processes. This review provides an overview of various Pd-catalyzed trifluormethylation reactions covering literatures up to 2021.