连接体
神经科学
顶叶上小叶
楔前
顶叶下小叶
统计参数映射
海马旁回
萎缩
静息状态功能磁共振成像
纤维束成像
心理学
磁共振弥散成像
医学
病理
功能连接
颞叶
认知
磁共振成像
放射科
癫痫
作者
Haojie Chen,Aocai Yang,Weijie Huang,Lei Du,Bing Liu,Kuan Lv,Jixin Luan,Pianpian Hu,Amir Shmuel,Ni Shu,Guolin Ma
出处
期刊:NeuroImage
[Elsevier]
日期:2024-03-05
卷期号:290: 120555-120555
被引量:3
标识
DOI:10.1016/j.neuroimage.2024.120555
摘要
Aberrant susceptibility due to iron level abnormality and brain network disconnections are observed in Alzheimer's disease (AD), with disrupted iron homeostasis hypothesized to be linked to AD pathology and neuronal loss. However, whether associations exist between abnormal quantitative susceptibility mapping (QSM), brain atrophy, and altered brain connectome in AD remains unclear. Based on multi-parametric brain imaging data from 30 AD patients and 26 healthy controls enrolled at the China-Japan Friendship Hospital, we investigated the abnormality of the QSM signal and volumetric measure across 246 brain regions in AD patients. The structural and functional connectomes were constructed based on diffusion MRI tractography and functional connectivity, respectively. The network topology was quantified using graph theory analyses. We revealed seven brain regions with both reduced cortical thickness and abnormal QSM (p<0.05) in AD, including right the superior frontal gyrus, left superior temporal gyrus, right fusiform gyrus, left superior parietal lobule, right superior parietal lobule, left inferior parietal lobule, and left precuneus. Correlations computed across subjects between cortical thickness and network topology specific to the AD group resulted in statistically significant correlations in five of these regions, with higher correlations in functional compared to structural topology. We computed the correlation between network topological metrics, QSM value and cortical thickness across regions at both individual and group-averaged levels, resulting in a measure we call spatial correlations. Decreased spatial correlation of QSM and global efficiency of the structural network was also found in AD patients at the individual level. These findings may provide insights into the complex relationships among QSM, brain atrophy, and brain connectome in AD.
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