Effect of dietary phosphorus deprivation during the dry period on the liver transcriptome of high-yielding periparturient dairy cows

冰崩解 哺乳期 动物科学 生物 怀孕 内分泌学 产后 断奶 内科学 奶牛 医学 遗传学
作者
Robert Ringseis,Sophia Wächter,Imke Cohrs,Klaus Eder,Walter Grünberg
出处
期刊:Journal of Dairy Science [Elsevier BV]
卷期号:107 (7): 5178-5189 被引量:1
标识
DOI:10.3168/jds.2023-24099
摘要

While dietary phosphorus (P) deprivation extending from the dry period into early lactation impairs health and productivity of cows, restricting dietary P supply during the dry period not only appears to be innocuous but rather effectively mitigates hypocalcemia during the first wk of lactation. To investigate possible negative metabolic effects of P deprivation during the dry period, the present study tested the hypothesis that restarted dietary P supply during the dry period alters the liver transcriptome of dairy cows during the periparturient period. Thirty late-pregnant multiparous Holstein-Friesian dairy cows entering their 2nd, 3rd or 4th lactation were assigned to either a dry cow ration with low (LP, 0.16% P in DM) or adequate P content (AP, 0.35% in DM) during the last 4 wk of the dry period (n = 15/group). Liver transcriptomics, which was carried out in a subset of 5 2nd parity cows of each group (n = 5), and determination of selected hormones and metabolites in blood of all cows, was performed approximately one wk before calving and on d 3 postpartum. Liver tissue specimens and blood samples were obtained by a micro-invasive biopsy technique from the right 10th intercostal space and puncture of a jugular vein, respectively. 175 hepatic transcripts were expressed differentially between LP vs. AP cows in late pregnancy, and 165 transcripts differed between LP vs. AP cows in early lactation (Fold change >1.3 and < −1.3, P < 0.05). In late pregnancy, the enriched biological processes of the upregulated and the downregulated transcripts were mainly related to immune processes and signal transduction (P < 0.05), respectively. In early lactation, the enriched biological processes of the upregulated and the downregulated transcripts were involved in mineral transport and biotransformation (P < 0.05), respectively. The plasma concentrations of the hormones and acute phase proteins (progesterone, insulin-like growth factor 1, serum amyloid α, haptoglobin, and 17β-estradiol) determined were not affected by P supply. These results suggest that P deprivation during the dry period moderately affects the liver transcriptome of cows in late pregnancy and early lactation, and causes no effects on important plasma hormones and acute phase proteins indicating no obvious impairment of health or metabolism of the cows.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李爱国应助vergil采纳,获得10
刚刚
王晚意123关注了科研通微信公众号
1秒前
研友_VZG7GZ应助trayheep采纳,获得10
1秒前
小段完成签到,获得积分10
1秒前
1秒前
bkagyin应助wwz采纳,获得10
1秒前
ezekiet完成签到 ,获得积分10
1秒前
2秒前
汉堡包应助kkk采纳,获得10
2秒前
退而求其次完成签到,获得积分10
3秒前
MinQi完成签到,获得积分10
3秒前
毛彬发布了新的文献求助10
3秒前
吴媛媛完成签到 ,获得积分10
3秒前
4秒前
鲤鱼一手发布了新的文献求助10
4秒前
lingjing完成签到,获得积分10
4秒前
华仔应助Tetrahydron采纳,获得30
5秒前
量子星尘发布了新的文献求助10
5秒前
慈祥的冬瓜完成签到,获得积分10
5秒前
5秒前
Mira完成签到,获得积分10
6秒前
温柔手机完成签到,获得积分10
6秒前
6秒前
Lindsay完成签到,获得积分10
7秒前
巧克力完成签到 ,获得积分10
7秒前
7秒前
7秒前
8秒前
8秒前
fengyuenanche完成签到,获得积分10
8秒前
8秒前
9秒前
10秒前
一瓶水发布了新的文献求助10
10秒前
橙子发布了新的文献求助10
10秒前
乐乐发布了新的文献求助20
11秒前
未来发布了新的文献求助10
11秒前
lalafish发布了新的文献求助10
12秒前
oyxz完成签到,获得积分10
12秒前
柔弱小之发布了新的文献求助10
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3986829
求助须知:如何正确求助?哪些是违规求助? 3529292
关于积分的说明 11244137
捐赠科研通 3267685
什么是DOI,文献DOI怎么找? 1803843
邀请新用户注册赠送积分活动 881223
科研通“疑难数据库(出版商)”最低求助积分说明 808600