模式
计算生物学
纳米技术
分子成像
计算机科学
数据科学
材料科学
生物
生物技术
体内
社会科学
社会学
作者
Ying Xu,Junfan Chen,Yuan Zhang,Pengcheng Zhang
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2024-03-04
卷期号:25 (4): 2222-2242
标识
DOI:10.1021/acs.biomac.3c01413
摘要
Recent strides in molecular pathology have unveiled distinctive alterations at the molecular level throughout the onset and progression of diseases. Enhancing the in vivo visualization of these biomarkers is crucial for advancing disease classification, staging, and treatment strategies. Peptide-based molecular probes (PMPs) have emerged as versatile tools due to their exceptional ability to discern these molecular changes with unparalleled specificity and precision. In this Perspective, we first summarize the methodologies for crafting innovative functional peptides, emphasizing recent advancements in both peptide library technologies and computer-assisted peptide design approaches. Furthermore, we offer an overview of the latest advances in PMPs within the realm of biological imaging, showcasing their varied applications in diagnostic and therapeutic modalities. We also briefly address current challenges and potential future directions in this dynamic field.
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