Smart Drug Release Systems Based on Stimuli-Responsive Polymers
智能聚合物
药品
控制释放
化学
计算机科学
作者
Guangyan Qing,Minmin Li,Lijing Deng,Ziyu Lv,Peng Ding,Taolei Sun
出处
期刊:Mini-reviews in Medicinal Chemistry [Bentham Science] 日期:2013-06-30卷期号:13 (9): 1369-1380被引量:27
标识
DOI:10.2174/13895575113139990062
摘要
Stimuli-responsive polymers could respond to external stimuli, such as temperature, pH, photo-irradiation,
electric field, biomolecules in solution, etc., which further induce reversible transformations in the structures
and conformations of polymers, providing an excellent platform for controllable drug release, while the accuracy of
drug delivery could obtain obvious improvement in this system. In this review, recent progresses in the drug release
systems based on stimuli-responsive polymers are summarized, in which drugs can be released in an intelligent mode with
high accuracy and efficiency, while potential damages to normal cells and tissues can also be effectively prevented owing
to the unique characteristics of materials. Moreover, we introduce some smart nanoparticles-polymers conjugates and
drug release devices, which are especially suitable for the long-term sustained drug release.