胃排空
运动性
内科学
阿托品
多巴胺
医学
胃肠道
药理学
化学
胃肠病学
胃
内分泌学
传统医学
生物
遗传学
作者
Yoshiyuki Kimura,Maho Sumiyoshi
出处
期刊:Fitoterapia
[Elsevier]
日期:2011-09-01
卷期号:82 (6): 827-833
被引量:32
标识
DOI:10.1016/j.fitote.2011.04.008
摘要
The Swertia japonica is used clinically as a remedy for gastrointestinal symptoms in Japan. We examined the effects of a S. japonica and swertiamarin on gastric emptying and gastrointestinal motility in atropine-, dopamine-, and 5-hydroxytryptamine (5-HT)-treated mice. All three preparations inhibited reductions in gastric emptying and gastrointestinal motility induced by dopamine (1 mg/kg, intraperitoneal injection, ip). Neither the powder, swertiamarin, nor itopride had any effect on the reductions in gastric emptying and gastrointestinal motility caused by 5-HT (4 mg/kg, ip). These findings suggest that the powder and swertiamarin stimulate gastric emptying and gastrointestinal motility by inhibiting the dopamine D2 receptor.
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