氯化十六烷基吡啶
克鲁斯假丝酵母
白色念珠菌
生物膜
洗必泰
肉汤微量稀释
微生物学
最小抑制浓度
氟康唑
白色体
化学
抗菌剂
食品科学
生物
抗真菌
牙科
医学
肺表面活性物质
生物化学
细菌
遗传学
作者
Jing Fu,Peng Wei,Zhao Chen,Chunhua He,Zhimin Yan,Hong Hua
出处
期刊:Oral Diseases
[Wiley]
日期:2014-04-12
卷期号:20 (8): 815-820
被引量:24
摘要
Objective To investigate the antifungal ability of seven over‐the‐counter mouthwashes against planktonic and sessile C andida albicans and C andida krusei . Materials and Methods The seven mouthwashes studied were Listerine ® , compound chlorhexidine solution, povidone iodine solution (PV‐I), cetylpyridinium chloride solution, Colgate ® Plax, Crest ® Prohealth Mouthwash, and Na HCO 3 . The antifungal ability of each mouthwash against ATCC 90028, ATCC 6258, and 10 clinical C . albicans isolates was tested using disk diffusion tests, the broth microdilution method, and biofilm testing with two different XTT ‐reduction assays. Fluconazole was used as a positive control, and the experiments were performed in triplicate. Results Chlorhexidine and cetylpyridinium chloride had the largest inhibition zones for ATCC 90028 and ATCC 6258 (18.6 ± 3.5 and 19 ± 1.6 mm, respectively). Cetylpyridinium chloride was the most effective at inhibiting all of the planktonic C . albicans strains and ATCC 6258 with the minimum inhibitory concentration (MIC). As the maturity of the biofilms increased, the change in sessile cell MIC of the mouthwashes was much smaller than that of fluconazole. For the mature biofilms, chlorhexidine, PV‐I, and cetylpyridinium chloride produced the greatest reductions in metabolism (60–80%). Conclusion Most of these seven mouthwashes had significant antifungal activity for both planktonic and sessile Candida species.
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