认知
迷走神经电刺激
神经化学
心理学
神经科学
癫痫
神经学
刺激
抗抑郁药
迷走神经
医学
海马体
作者
Kristl Vonck,Robrecht Raedt,Joke Naulaerts,Frederick De Vogelaere,Evert Thiery,Pascal Doguet,Bert Aldenkamp,Marijke Miatton,Paul Boon
标识
DOI:10.1016/j.neubiorev.2014.05.005
摘要
VNS therapy was delivered to patients for the first time in 1988. After 25 years, insight in the antiepileptic and antidepressant mechanism of action of VNS has grown steadily. The effects on cognition and especially memory remain controversial. This review provides an elaborate overview of studies addressing cognition and describes potential underlying mechanisms for the reported effects. Short-term VNS has an effect on verbal memory recognition when administered at the correct timing and dosage. Chronic VNS resulted into a positive effect on the cognitive status in an Alzheimer population. Positive effect of chronic VNS in epilepsy or depression patients on global cognitive functioning are less convincing. Neither do the results reveal a negative effect which has major implications for chronic treatment of neurology patients. A cascade of neurochemical processes put in motion by changes in NE concentrations in reaction to stimulation of the vagal nerve may underlie the VNS-induced effects on cognition and memory. In Alzheimer pathology, NE may act as an anti-inflammatory agent on brainstem nuclei.
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