免疫监视
生物
免疫系统
主要组织相容性复合体
抗原
细胞毒性T细胞
免疫学
T细胞
抗原提呈细胞
癌症研究
体外
生物化学
作者
Alexandre Corthay,Dag K. Skovseth,Katrin U. Lundin,Egil Røsjø,Hilde Omholt,Peter O. Hofgaard,Guttorm Haraldsen,Bjarne Bogen
出处
期刊:Immunity
[Elsevier]
日期:2005-03-01
卷期号:22 (3): 371-383
被引量:436
标识
DOI:10.1016/j.immuni.2005.02.003
摘要
Gene-targeted mice have recently revealed a role for lymphocytes and interferon-γ (IFNγ) in conferring protection against cancer, but the mechanisms remain unclear. Here, we have characterized a successful primary antitumor immune response initiated by naive CD4+ T cells. Major histocompatibility complex class II (MHC-II)-negative myeloma cells injected subcutaneously into syngeneic mice were surrounded within 3 days by macrophages that captured tumor antigens. Within 6 days, naive myeloma-specific CD4+ T cells became activated in draining lymph nodes and subsequently migrated to the incipient tumor site. Upon recognition of tumor-derived antigenic peptides presented on MHC-II by macrophages, the myeloma-specific CD4+ T cells were reactivated and started to secrete cytokines. T cell-derived IFNγ activated macrophages in close proximity to the tumor cells. Tumor cell growth was completely inhibited by such locally activated macrophages. These data indicate a mechanism for immunosurveillance of MHC-II-negative cancer cells by tumor-specific CD4+ T cells through collaboration with macrophages.
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