生物
高海拔对人类的影响
表型
适应(眼睛)
基因
人口
进化生物学
基因组
遗传学
单倍型
缺氧(环境)
计算生物学
等位基因
医学
神经科学
环境卫生
解剖
有机化学
化学
氧气
作者
Tatum S. Simonson,Yingzhong Yang,Chad Huff,Hu Yun,Qin Ga,David J. Witherspoon,Zhenzhong Bai,Felipe Lorenzo,Jinchuan Xing,Lynn B. Jorde,Josef T. Prchal,Ri Li Ge
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2010-07-02
卷期号:329 (5987): 72-75
被引量:943
标识
DOI:10.1126/science.1189406
摘要
No Genetic Vertigo Peoples living in high altitudes have adapted to their situation (see the Perspective by Storz ). To identify gene regions that might have contributed to high-altitude adaptation in Tibetans, Simonson et al. (p. 72 , published online 13 May) conducted a genome scan of nucleotide polymorphism comparing Tibetans, Han Chinese, and Japanese, while Yi et al. (p. 75 ) performed comparable analyses on the coding regions of all genes—their exomes. Both studies converged on a gene, endothelial Per-Arnt-Sim domain protein 1 (also known as hypoxia-inducible factor 2 α), which has been linked to the regulation of red blood cell production. Other genes identified that were potentially under selection included adult and fetal hemoglobin and two functional candidate loci that were correlated with low hemoglobin concentration in Tibetans. Future detailed functional studies will now be required to examine the mechanistic underpinnings of physiological adaptation to high altitudes.
科研通智能强力驱动
Strongly Powered by AbleSci AI