化学
残留物(化学)
生物催化
缬氨酸
青霉胺
肽
天然产物
肽合成
绿色化学
立体化学
产量(工程)
苏氨酸
氨基酸
有机化学
反应机理
催化作用
生物化学
丝氨酸
酶
材料科学
冶金
作者
Michelle S. Y. Wong,Deni Taleski,Katrina A. Jolliffe
摘要
The total synthesis of cyclic hexapeptide dichotomin A from linear peptide precursors containing penicillamine-derived pseudoproline residues is reported. The incorporation of a pseudoproline residue led to a faster reaction and higher head-to-tail cyclization yields in comparison to linear precursors containing the native valine residue. However, deprotection of the pseudoproline resulted in significant amounts of a by-product in which a threonine side chain had undergone dehydration, resulting in a low overall yield of the natural product.
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