殖民抵抗
微生物学
共生
生物
抗生素
殖民地化
免疫系统
屎肠球菌
微生物群
抗生素耐药性
细菌
免疫学
生物信息学
遗传学
作者
Charlie G. Buffie,Eric G. Pamer
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2013-10-07
卷期号:13 (11): 790-801
被引量:1296
摘要
Commensal bacteria inhabit mucosal and epidermal surfaces in mice and humans, and have effects on metabolic and immune pathways in their hosts. Recent studies indicate that the commensal microbiota can be manipulated to prevent and even to cure infections that are caused by pathogenic bacteria, particularly pathogens that are broadly resistant to antibiotics, such as vancomycin-resistant Enterococcus faecium, Gram-negative Enterobacteriaceae and Clostridium difficile. In this Review, we discuss how immune- mediated colonization resistance against antibiotic-resistant intestinal pathogens is influenced by the composition of the commensal microbiota. We also review recent advances characterizing the ability of different commensal bacterial families, genera and species to restore colonization resistance to intestinal pathogens in antibiotic-treated hosts.
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