生物
炎症
癌症
表型
免疫学
功能(生物学)
趋化性
抑制器
癌细胞
癌症研究
细胞生物学
遗传学
基因
受体
作者
Jitka Yehudith Sagiv,Janna Michaeli,Simaan Assi,Inbal Mishalian,Hen Kisos,Liran Levy,Pazzit Damti,Delphine Lumbroso,Lola Polyansky,Ronit Vogt Sionov,Amiram Ariel,Avi‐Hai Hovav,Erik Henke,Zvi G. Fridlender,Zvi Granot
出处
期刊:Cell Reports
[Cell Press]
日期:2015-01-22
卷期号:10 (4): 562-573
被引量:707
标识
DOI:10.1016/j.celrep.2014.12.039
摘要
Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro- and antitumor functions. We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs display impaired neutrophil function and immunosuppressive properties, characteristics that are in stark contrast to those of mature, high-density neutrophils (HDNs). LDNs consist of both immature myeloid-derived suppressor cells (MDSCs) and mature cells that are derived from HDNs in a TGF-β-dependent mechanism. Our findings identify three distinct populations of circulating neutrophils and challenge the concept that mature neutrophils have limited plasticity. Furthermore, our findings provide a mechanistic explanation to mitigate the controversy surrounding neutrophil function in cancer.
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