T细胞受体
蛋白质酪氨酸磷酸酶
脱磷
T细胞
磷酸化
细胞生物学
酪氨酸磷酸化
负调节器
信号转导
酪氨酸
调节器
生物
Jurkat细胞
CTLA-4号机组
化学
磷酸酶
免疫学
免疫系统
生物化学
基因
作者
Kyung Mi Lee,Ellen Chuang,Matthew D. Griffin,Roli Khattri,David K. Hong,Weiguo Zhang,David B. Straus,Lawrence E. Samelson,Craig B. Thompson,Jeffrey A. Bluestone
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1998-12-18
卷期号:282 (5397): 2263-2266
被引量:629
标识
DOI:10.1126/science.282.5397.2263
摘要
CTLA-4, a negative regulator of T cell function, was found to associate with the T cell receptor (TCR) complex zeta chain in primary T cells. The association of TCRzeta with CTLA-4, reconstituted in 293 transfectants, was enhanced by p56(lck)-induced tyrosine phosphorylation. Coexpression of the CTLA-4-associated tyrosine phosphatase, SHP-2, resulted in dephosphorylation of TCRzeta bound to CTLA-4 and abolished the p56(lck)-inducible TCRzeta-CTLA-4 interaction. Thus, CTLA-4 inhibits TCR signal transduction by binding to TCRzeta and inhibiting tyrosine phosphorylation after T cell activation. These findings have broad implications for the negative regulation of T cell function and T cell tolerance.
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