MAPK/ERK通路
细胞生物学
体细胞
蛋白激酶A
丝裂原活化蛋白激酶
生物
激酶
MAPK级联
细胞周期
胚胎
磷酸化
信号转导
细胞周期蛋白依赖激酶2
丝裂原活化蛋白激酶3
细胞
生物化学
基因
作者
Naoki Iwamori,Kunihiko Naito,Koji Sugiura,Hideyuki Kagii,Masakane Yamashita,Satoshi Ohashi,Seitaro Goto,Keitaro Yamanouchi,Hideaki Tojo
摘要
The mitogen-activated protein kinase (MAPK) cascade is one of the most important signal transduction pathways that regulate the cell cycle in somatic cells. The present study examined the phosphorylation states of components in the MAPK cascade, Raf-1, MEK-1, and extracellular signal regulated kinases (ERKs), which are activated by mitogens, throughout early mouse embryo development and in cultured somatic cells generally. In somatic cells, Raf-1 and MEK-1 were phosphorylated at M-phase and dephosphorylated during interphase. ERKs were not phosphorylated at any stage during the cell cycle. These results were similar to previous findings for the first and second cell cycles of early mouse embryos. In contrast, after the four-cell stage, not only ERKs, but also Raf-1 and MEK-1, were not phosphorylated at any stage during the cell cycle in mouse early embryos. These results suggest that the MAPK cascade in mouse embryos is regulated by the same mechanism as in somatic cells before the two-cell stage, and that regulation is changed to an embryo-specific mechanism after the four-cell stage.
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