质谱成像
质谱法
分子成像
表面增强激光解吸/电离
化学
分析物
基质辅助激光解吸/电离
基质(化学分析)
马尔迪成像
医学
解吸
计算生物学
分析化学(期刊)
病理
色谱法
蛋白质质谱法
生物
串联质谱法
吸附
生物技术
有机化学
体内
作者
Kristina Schwamborn,Richard M. Caprioli
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2010-08-19
卷期号:10 (9): 639-646
被引量:321
摘要
Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
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