灌注
血流动力学
血流
生物医学工程
微循环
材料科学
剪应力
医学
心脏病学
内科学
复合材料
作者
Charlotte Debbaut,Diethard Monbaliu,Christophe Casteleyn,Pieter Cornillie,Denis Van Loo,Bert Masschaele,Jacques Pirenne,Paul Simoens,Luc Van Hoorebeke,Patrick Segers
出处
期刊:IEEE Transactions on Biomedical Engineering
[Institute of Electrical and Electronics Engineers]
日期:2011-01-01
卷期号:58 (1): 25-35
被引量:74
标识
DOI:10.1109/tbme.2010.2065229
摘要
Hypothermic machine perfusion (HMP) is experiencing a revival in organ preservation due to the limitations of static cold storage and the need for better preservation of expanded criteria donor organs. For livers, perfusion protocols are still poorly defined, and damage of sinusoidal endothelial cells and heterogeneous perfusion are concerns. In this study, an electrical model of the human liver blood circulation is developed to enlighten internal pressure and flow distributions during HMP. Detailed vascular data on two human livers, obtained by combining vascular corrosion casting, micro-CT-imaging and image processing, were used to set up the electrical model. Anatomical data could be measured up to 5--6 vessel generations in each tree and showed exponential trend lines, used to predict data for higher generations. Simulated flow and pressure were in accordance with literature data. The model was able to simulate effects of pressure-driven HMP on liver hemodynamics and reproduced observations such as flow competition between the hepatic artery and portal vein. Our simulations further indicate that, from a pure biomechanical (shear stress) standpoint, HMP with low pressures should not result in organ damage, and that fluid viscosity has no effect on the shear stress experienced by the liver microcirculation in pressure-driven HMP.
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