G蛋白偶联受体
内化
功能(生物学)
表型
生物
受体
细胞生物学
计算生物学
细胞
信号转导
视紫红质样受体
细胞功能
细胞信号
生物化学
兴奋剂
基因
代谢受体
出处
期刊:PubMed
日期:2005-01-01
卷期号:48: 31-4
被引量:6
摘要
G protein coupled receptors (GPCRs) are an important class of ligand-activated proteins that regulate cellular metabolism. It is now appears that GPCR function is highly dependent upon the cellular environment in which it is expressed. Indeed, the cell phenotype influences several sequelae of GPCR activation, including GPCR oligomerization, G protein coupling, spatial organization of signaling proteins and inactivation and internalization processes. The cell phenotype, consequently, modulates both the affinity and efficacy of endogenous agonists and synthetic compounds. Emerging data suggests a complex function of GPCR signaling resulting in tissue specific responses, even those emanating from the same GPCR subtype. This short review describes some phenotypic influences on GPCR function and their implications for the use of cell-based assays used to identify and characterize GPCR ligands.
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