To establish a method to determine Vitamin C in the Vc Yinqiao Tablets.Diffuse Reflectance in FTIR was used to determination of Vitamin C in the Vc Yinqiao tablets.The content of Vitamin C could be obtained directly, and the relationship between the absorbance and the concen tration was linear. The average recovery rate of Vitamin C was 98.69%, and RSD was 0.33%.The method is simple, accurate and reliable, which may well be used for the determination of Vitamin C in the Vc Yinqiao Tablet.