重症肌无力
医学
白蛋白
灌注
乙酰胆碱受体
体外
色谱法
等离子体
抗体
吸附
乙酰胆碱
内科学
免疫学
化学
受体
生物化学
有机化学
吸附
物理
量子力学
作者
Koji Sawada,P. S. Malchesky,Anna P. Koo,Hiroshi Mitsumoto
出处
期刊:Cleveland Clinic Journal of Medicine
[Cleveland Clinic Journal of Medicine]
日期:1993-01-01
卷期号:60 (1): 60-64
被引量:9
摘要
This in vitro study assessed the effectiveness of a new immunoadsorbent (Asahi IM-TR 350) in removing anti-acetylcholine receptor antibody from plasma with minimal loss of albumin. Plasma procured from a myasthenia gravis patient undergoing routine plasma exchange was perfused through the immunoadsorbent and recirculated in vitro to simulate a clinical treatment. To assess the temperature dependency of sorption, perfusion was performed at various temperatures. Plasma solute concentrations were taken before and after perfusion to calculate solute rejection coefficients. The immunoadsorbent has a high sorption capacity for anti-acetylcholine receptor antibody, while allowing a minimum loss of albumin. For patients with myasthenia gravis, this immunoadsorbent can provide an alternative to plasma exchange that does not require the use of plasma products.
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