医学
胃肠病学
自身免疫性肝炎
内科学
肝功能检查
病因学
肝活检
鉴别诊断
脂肪肝
非酒精性脂肪肝
恶性肿瘤
肝病
肝功能
病毒性肝炎
原发性胆汁性肝硬化
病理
肝炎
疾病
活检
作者
Shu-zhen Pang,Xiaojuan Ou,Xiaoyan Shi,Tailing Wang,Weijia Duan,Ji-dong Jia
出处
期刊:PubMed
日期:2011-01-01
卷期号:50 (1): 36-9
被引量:3
摘要
To evaluate the clinical and histological features of patients with abnormal liver tests of unknown etiology, and then to investigate the diagnosis and differential diagnosis.Patients with abnormal liver function test hospitalized and had liver biopsies during 2008 - 2009 constituted this retrospective study cohort. After excluding those patients diagnosed with hepatotropic viral hepatitis, space occupying lesions of the liver, alcoholic liver disease and obstruction of bile duct caused by stone or malignancy and AMA/AMA-M(2) positive of primary biliary cirrhosis (PBC), the clinical and histological characteristics were evaluated.Out of the 180 patients who underwent liver biopsy, 88 patients were included in the present analysis. The final diagnosis involved 15 categories of diseases, with drug-induced liver injury (DILI) [34.09% (30/88)], autoimmune liver diseases [22.73% (20/88)], and nonalcoholic fatty liver disease (NAFLD) [12.50% (11/88)] being the most common causes, following by genetic and other rare diseases.DILI, autoimmune liver disease and NAFLD were the most common causes of abnormal liver tests in these non-viral liver diseases. Some rare diseases such as hereditary metabolic liver disease also represent a considerable proportion in patients with abnormal liver function test.
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