微生物群
益生元
肠道菌群
肠道微生物群
代谢组学
生物
免疫系统
疾病
生物信息学
免疫
炎症
失调
计算生物学
免疫学
医学
遗传学
内科学
作者
Benoît Foligné,Jérôme Breton,Denis D.G. Mater,Gwénaël Jan
出处
期刊:Gut
[BMJ]
日期:2013-02-06
卷期号:62 (8): 1227-1228
被引量:38
标识
DOI:10.1136/gutjnl-2012-304393
摘要
We read with great interest the recent study by Dewulf and coworkers1 reporting encouraging results on a prebiotic-based dietary intervention trial in obese patients. This work enlightens that even subtle changes in the gut microbiota may influence the metabolomic signature both inside and outside the gut. Interplay among diet, immunity and microbial and host metabolism results in a complex multidirectional signalling that is critical in the maintenance of a healthy gut functionality, reducing risks for inflammatory bowel diseases and metabo-inflammation states associated with obesity.2 ,3 In parallel, the ‘omics’ era has produced many observations associated with disease states,4 and the correlation among the presence, absence or specific ratios of certain bacterial phyla, orders or genera can be considered as a strategy to directly or indirectly manipulate the microbiome. However, a clear causal molecular link between a specific microbial community and a specific metabolic or immune profile is …
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