神经科学
结构塑性
海马体
神经发生
海马结构
心理学
变质塑性
神经可塑性
可塑性
突触
认知心理学
突触可塑性
认知科学
生物
生物化学
物理
受体
热力学
作者
Benedetta Leuner,Elizabeth Gould
出处
期刊:Annual Review of Psychology
[Annual Reviews]
日期:2010-01-01
卷期号:61 (1): 111-140
被引量:384
标识
DOI:10.1146/annurev.psych.093008.100359
摘要
The hippocampus is a region of the mammalian brain that shows an impressive capacity for structural reorganization. Preexisting neural circuits undergo modifications in dendritic complexity and synapse number, and entirely novel neural connections are formed through the process of neurogenesis. These types of structural change were once thought to be restricted to development. However, it is now generally accepted that the hippocampus remains structurally plastic throughout life. This article reviews structural plasticity in the hippocampus over the lifespan, including how it is investigated experimentally. The modulation of structural plasticity by various experiential factors as well as the possible role it may have in hippocampal functions such as learning and memory, anxiety, and stress regulation are also considered. Although significant progress has been made in many of these areas, we highlight some of the outstanding issues that remain.
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