An operational transformation of 3-carboxy-4-quinolones into 3-nitro-4-quinolones via ipso-nitration using polysaccharide supported copper nanoparticles: synthesis of 3-tetrazolyl bioisosteres of 3-carboxy-4-quinolones as antibacterial agents

The 3-nitro-4-quinolones have been synthesizedviaipso nitration of 3-carboxy-4-quinolones by chitosan supported Cu nano-particles. The 3-nitro derivatives were converted into their 3-tetrazolyl bioisosteres which showed increased antibacterial activity.