Synthesis of (−)‐(Z)‐Deoxypukalide

Closing the deal: A ring-closing metathesis (RCM)/aromatization protocol, followed by a regioselective Negishi cross-coupling reaction and macrolactonization, with subsequent RCM mediate the synthesis of (−)-(Z)-deoxypukalide in 12 linear steps and 15 % overall yield (see retrosynthesis; TBS=tert-butyldimethylsilyl, TIPS=triisopropylsilyl). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z802703_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.