Profiling of Active Thrombin in Human Blood by Supramolecular Complexes

Angewandte Chemie International EditionVolume 50, Issue 27 p. 6075-6078 Communication Profiling of Active Thrombin in Human Blood by Supramolecular Complexes† Dr. Jens Müller, Dr. Jens Müller Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorTobias Becher, Tobias Becher Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorJennifer Braunstein, Jennifer Braunstein Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorDr. Philipp Berdel, Dr. Philipp Berdel Clinic for Orthopedic Surgery, 53105 Bonn (Germany)Search for more papers by this authorDr. Sascha Gravius, Dr. Sascha Gravius Clinic for Orthopedic Surgery, 53105 Bonn (Germany)Search for more papers by this authorFalk Rohrbach, Falk Rohrbach Life and Medical Sciences Institute, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany), Fax: (+49) 228-734809 www.mayerlab.deSearch for more papers by this authorProf. Dr. Johannes Oldenburg, Prof. Dr. Johannes Oldenburg Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorProf. Dr. Günter Mayer, Corresponding Author Prof. Dr. Günter Mayer [email protected] Life and Medical Sciences Institute, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany), Fax: (+49) 228-734809 www.mayerlab.de Günter Mayer, Life and Medical Sciences Institute, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany), Fax: (+49) 228-734809 www.mayerlab.de Bernd Pötzsch, Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorProf. Dr. Bernd Pötzsch, Corresponding Author Prof. Dr. Bernd Pötzsch [email protected] Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany) Günter Mayer, Life and Medical Sciences Institute, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany), Fax: (+49) 228-734809 www.mayerlab.de Bernd Pötzsch, Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this author Dr. Jens Müller, Dr. Jens Müller Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorTobias Becher, Tobias Becher Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorJennifer Braunstein, Jennifer Braunstein Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorDr. Philipp Berdel, Dr. Philipp Berdel Clinic for Orthopedic Surgery, 53105 Bonn (Germany)Search for more papers by this authorDr. Sascha Gravius, Dr. Sascha Gravius Clinic for Orthopedic Surgery, 53105 Bonn (Germany)Search for more papers by this authorFalk Rohrbach, Falk Rohrbach Life and Medical Sciences Institute, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany), Fax: (+49) 228-734809 www.mayerlab.deSearch for more papers by this authorProf. Dr. Johannes Oldenburg, Prof. Dr. Johannes Oldenburg Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorProf. Dr. Günter Mayer, Corresponding Author Prof. Dr. Günter Mayer [email protected] Life and Medical Sciences Institute, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany), Fax: (+49) 228-734809 www.mayerlab.de Günter Mayer, Life and Medical Sciences Institute, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany), Fax: (+49) 228-734809 www.mayerlab.de Bernd Pötzsch, Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this authorProf. Dr. Bernd Pötzsch, Corresponding Author Prof. Dr. Bernd Pötzsch [email protected] Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany) Günter Mayer, Life and Medical Sciences Institute, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany), Fax: (+49) 228-734809 www.mayerlab.de Bernd Pötzsch, Institute for Experimental Haematology and Transfusion Medicine, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)Search for more papers by this author First published: 17 May 2011 https://doi.org/10.1002/anie.201007032Citations: 64 † We thank T. Kupper and B. Wulffen for skilful technical assistance. This work was supported by the BonFor Foundation (T.B. and J.B.) and by funds from the German Research Council (DFG; Ma 3442/1-2). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract To clot or not to clot: The coagulation system is a multienzymatic network associated with bleeding or thrombosis in patients. A supramolecular oligonucleotide-adapted approach (see picture) makes thrombin, the key enzyme of this network, measurable in vivo. In patients undergoing hip-replacement surgery, thrombin was identified as a valuable biomarker to allow monitoring of the activity level of the coagulation system under clinical conditions. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201007032_sm_miscellaneous_information.pdf542.2 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume50, Issue27June 27, 2011Pages 6075-6078 RelatedInformation