Adverse childhood experiences and trajectories of multimorbidity in individuals aged over 50: Evidence from the English Longitudinal Study of Ageing

多发病率 医学 纵向研究 老化 慢性病 共病 人口学 多项式logistic回归 逻辑回归 老年学 内科学 疾病 儿科 机器学习 病理 社会学 计算机科学
作者
Katherine Taylor,Panayotes Demakakos
出处
期刊:Child Abuse & Neglect [Elsevier BV]
卷期号:149: 106653-106653 被引量:1
标识
DOI:10.1016/j.chiabu.2024.106653
摘要

Adverse childhood experiences (ACE) are important for chronic diseases yet their association with multimorbidity remains understudied. Few studies consider the complexity of multimorbidity or observe multimorbidity development over time. We investigated whether ACE were associated with multimorbidity at baseline and over a 12-year follow-up period. 5326 participants aged over 50 were obtained from the English Longitudinal Study of Ageing (ELSA). An ACE summary score was derived using eight ACE items measuring abuse, social care, and household dysfunction. From repeated measurements of 29 chronic conditions over a 12-year period (2008–2019) we derived two multimorbidity measures: number of chronic diseases and number of chronic disease categories. We used multinomial logistic regression to assess associations between ACE and both measures. Mixed effects models were estimated to examine trajectories of multimorbidity by ACE over time. Graded associations between ACE and multimorbidity were observed. Compared to those without ACE, participants with ≥3 ACE had three times the risk of having ≥3 chronic diseases (RRR 3.06, 95 % CI 1.85–5.05) and falling into ≥3 chronic disease categories (RRR 2·93 95 % CI 1·74–4·95). Graded associations persisted during 12-year follow-up, though differences in multimorbidity between those with ≥3 ACE and those without ACE remained constant (B 0.02, 95 % CI 0·01–0·03, and B −0·01, 95 % CI −0·02–0·00, number of chronic conditions and chronic condition categories respectively). ACE are associated with multimorbidity risk and complexity, associations arising before the age of 50. Early intervention amongst those with ACE could attenuate this association.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
阿良发布了新的文献求助10
刚刚
2秒前
tzj完成签到,获得积分10
2秒前
王者归来发布了新的文献求助200
2秒前
俏皮安双发布了新的文献求助10
3秒前
鱼yu发布了新的文献求助10
3秒前
吃饱了就晒太阳完成签到,获得积分10
4秒前
领导范儿应助hd采纳,获得10
4秒前
Awei发布了新的文献求助10
5秒前
5秒前
洗刷刷发布了新的文献求助10
6秒前
钱钱钱发布了新的文献求助10
7秒前
8秒前
TH发布了新的文献求助10
8秒前
dudu123完成签到,获得积分10
10秒前
yyds发布了新的文献求助10
11秒前
Atec发布了新的文献求助10
12秒前
orixero应助研友_Z6eOgn采纳,获得10
12秒前
13秒前
CipherSage应助victorchen采纳,获得10
15秒前
yyds完成签到,获得积分10
16秒前
思源应助dudu123采纳,获得10
16秒前
量子星尘发布了新的文献求助10
17秒前
直率的青寒完成签到,获得积分10
18秒前
hd发布了新的文献求助10
18秒前
21秒前
今后应助阿良采纳,获得10
22秒前
领导范儿应助堇笙vv采纳,获得10
25秒前
华仔应助凡人采纳,获得10
25秒前
25秒前
26秒前
隐形的觅波完成签到 ,获得积分10
27秒前
27秒前
毛毛发布了新的文献求助10
27秒前
Eunhyo完成签到,获得积分10
28秒前
随机昵称发布了新的文献求助10
29秒前
平湖凉月完成签到,获得积分10
30秒前
xifanfan完成签到 ,获得积分10
30秒前
adam发布了新的文献求助10
30秒前
包博发布了新的文献求助10
32秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975375
求助须知:如何正确求助?哪些是违规求助? 3519700
关于积分的说明 11199305
捐赠科研通 3256034
什么是DOI,文献DOI怎么找? 1798049
邀请新用户注册赠送积分活动 877386
科研通“疑难数据库(出版商)”最低求助积分说明 806305