纳米粒子跟踪分析
纳米颗粒
表征(材料科学)
材料科学
纳米技术
粒子(生态学)
折射率
光电子学
微泡
化学
小RNA
生物化学
海洋学
地质学
基因
作者
Minh‐Chau Nguyen,Peter Bonnaud,Rayane Dibsy,Guillaume Maucort,Sébastien Lyonnais,Delphine Muriaux,Pierre Bon
出处
期刊:Small
[Wiley]
日期:2023-11-27
卷期号:20 (16)
被引量:2
标识
DOI:10.1002/smll.202304564
摘要
Unknown particle screening-including virus and nanoparticles-are keys in medicine, industry, and also in water pollutant determination. Here, RYtov MIcroscopy for Nanoparticles Identification (RYMINI) is introduced, a staining-free, non-invasive, and non-destructive optical approach that is merging holographic label-free 3D tracking with high-sensitivity quantitative phase imaging into a compact optical setup. Dedicated to the identification and then characterization of single nano-object in solution, it is compatible with highly demanding environments, such as level 3 biological laboratories, with high resilience to external source of mechanical and optical noise. Metrological characterization is performed at the level of each single particle on both absorbing and transparent particles as well as on immature and infectious HIV, SARS-CoV-2 and extracellular vesicles in solution. The capability of RYMINI to determine the nature, concentration, size, complex refractive index and mass of each single particle without knowledge or model of the particles' response is demonstrated. The system surpasses 90% accuracy for automatic identification between dielectric/metallic/biological nanoparticles and ≈80% for intraclass chemical determination of metallic and dielectric. It falls down to 50-70% for type determination inside the biological nanoparticle's class.
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