医学
安慰剂
支气管扩张
痰
慢性阻塞性肺病
内科学
乙酰半胱氨酸
生活质量(医疗保健)
不利影响
随机对照试验
安慰剂对照研究
临床试验
肺
肺结核
双盲
病理
抗氧化剂
替代医学
化学
护理部
生物化学
作者
Lata Jayaram,Paul T. King,John E. Hunt,Michael Lim,C. Park,E. Hu,Lovisa Dousha,Patrick K. Ha,J. Blake Bartlett,Anne Marie Southcott,Sanjeevan Muruganandan,Sara Vogrin,Megan Rees,Olivia Dean,Conroy Wong
标识
DOI:10.1016/j.pupt.2023.102283
摘要
High dose N acetylcysteine (NAC), a mucolytic, anti-inflammatory and antioxidant agent has been shown to significantly reduce exacerbations, and improve quality of life in placebo controlled, double blind randomised (RCT) studies in patients with COPD, and in an open, randomised study in bronchiectasis. In this pilot, randomised, double-blind, placebo-controlled study, we wished to investigate the feasibility of a larger clinical trial, and the anti-inflammatory and clinical benefits of high dose NAC in bronchiectasis.
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