Fabrication of reversible bacteria-killing and bacteria-releasing cotton fabrics with anti-bacteria adhesion capacity for potential application in reusable medical materials

Nowadays, more and more smart antibacterial materials have been prepared to meet some specific application area, and most of these materials have complex fabrication processes or incompatible biocompatibility. In this paper, a smart monomer that can switch between the form of quaternary ammonium salt and zwitterionic betaine was prepared and grafted onto cotton fabric. This finished cotton was smart too, it had nice antibacterial performance (99.89 % for E. coli and 99.97 % for S. aureus) in the form of quaternary ammonium salt, and it could release most of the attached bacteria when transferred to the form of zwitterionic betaine in PBS, and the form of zwitterionic betaine could converse back to the state of quaternary ammonium salt in HAC. Simultaneously, it was biocompatible in the form of zwitterionic betaine form. Furthermore, this smart material had nice function reproducibility after repeated transformations. In general, the smart antibacterial cotton could switch between bacteria-killing and bacteria-releasing reversibly, and had good biocompatibility and nice reproducibility, showing a potential application in reusable medical protective materials.