佐剂
免疫系统
抗原
卵清蛋白
免疫增强剂
抗体效价
免疫疗法
抗体
医学
化学
免疫学
效价
作者
Xiuli Zhang,Mingjing Wei,Zhigang Zhang,Yarong Zeng,Fengming Zou,Sibo Zhang,Zhiping Wang,Fentian Chen,Hualong Xiong,Yufang Li,Lizhi Zhou,Tingting Li,Qingbing Zheng,Hai Yu,Qian Zhang,Ying Gu,Qinjian Zhao,Shaowei Li,Ningshao Xia
标识
DOI:10.1016/j.jconrel.2024.01.033
摘要
The cGAS-STING pathway and the Mevalonate Pathway are druggable targets for vaccine adjuvant discovery. Manganese (Mn) and bisphosphonates are known to exert adjuvant effects by targeting these two pathways, respectively. This study found the synergistic potential of the two pathways in enhancing immune response. Risedronate (Ris) significantly amplified the Mn adjuvant early antibody response by 166-fold and fortified its cellular immunity. However, direct combination of Mn
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