医学
慢性阻塞性肺病
安慰剂
临床终点
充血
血压
伯德指数
内科学
随机对照试验
外科
心脏病学
病理
血流
肺康复
替代医学
作者
Ali Alasmari,Abdullah S Alsulayyim,Saeed M. Alghamdi,Keir Philip,Sara Buttery,Winston Banya,Michael I. Polkey,Paul C. Armstrong,Matthew Rickman,Timothy D. Warner,Jane A. Mitchell,Nicholas S Hopkinson
出处
期刊:The European respiratory journal
[European Respiratory Society]
日期:2023-12-20
卷期号:63 (2): 2202353-2202353
被引量:6
标识
DOI:10.1183/13993003.02353-2022
摘要
Background Short-term studies suggest that dietary nitrate (NO 3 − ) supplementation may improve the cardiovascular risk profile, lowering blood pressure (BP) and enhancing endothelial function. It is not clear if these beneficial effects are sustained and whether they apply in people with COPD, who have a worse cardiovascular profile than those without COPD. Nitrate-rich beetroot juice (NR-BRJ) is a convenient dietary source of nitrate. Methods The ON-BC trial was a randomised, double-blind, placebo-controlled parallel group study in stable COPD patients with home systolic BP (SBP) measurement ≥130 mmHg. Participants were randomly allocated (1:1) using computer-generated, block randomisation to either 70 mL NR-BRJ (400 mg NO 3 − ) (n=40) or an otherwise identical nitrate-depleted placebo juice (0 mg NO 3 − ) (n=41), once daily for 12 weeks. The primary end-point was between-group change in home SBP measurement. Secondary outcomes included change in 6-min walk distance (6MWD) and measures of endothelial function (reactive hyperaemia index (RHI) and augmentation index normalised to a heart rate of 75 beats·min −1 (AIx75)) using an EndoPAT device. Plasma nitrate and platelet function were also measured. Results Compared with placebo, active treatment lowered SBP (Hodges–Lehmann treatment effect −4.5 (95% CI −5.9– −3.0) mmHg), and improved 6MWD (30.0 (95% CI 15.7–44.2) m; p<0.001), RHI (0.34 (95% CI 0.03–0.63); p=0.03) and AIx75 (−7.61% (95% CI −14.3– −0.95%); p=0.026). Conclusions In people with COPD, prolonged dietary nitrate supplementation in the form of beetroot juice produces a sustained reduction in BP, associated with an improvement in endothelial function and exercise capacity.
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