Selenium: The Emerging Element in the Medicinal Chemist’s Toolkit

化学家 梅德林 中国 图书馆学 化学 医学 计算机科学 政治学 生物化学 有机化学 法学
作者
Lanmeng Cui,Wei Hou,Hongtao Xu
出处
期刊:Future Medicinal Chemistry [Future Science Ltd]
卷期号:16 (6): 493-496
标识
DOI:10.4155/fmc-2024-0041
摘要

Future Medicinal ChemistryVol. 16, No. 6 EditorialSelenium: the emerging element in the medicinal chemist's toolkitLanmeng Cui, Wei Hou & Hongtao XuLanmeng CuiCollege of Pharmaceutical Science & Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China, Wei Hou *Author for correspondence: E-mail Address: houwei@zjut.edu.cnhttps://orcid.org/0000-0002-9027-8991College of Pharmaceutical Science & Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China & Hongtao Xu **Author for correspondence: E-mail Address: xuht@shanghaitech.edu.cnhttps://orcid.org/0000-0001-5174-9079Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, ChinaPublished Online:20 Feb 2024https://doi.org/10.4155/fmc-2024-0041AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: biocompatibleDNA-encoded libraryparallel synthesisseleniumReferences1. Rayman MP. Selenium and human health. Lancet 379(9822), 1256–1268 (2012).Medline CASGoogle Scholar2. Hou W, Xu H. Incorporating selenium into heterocycles and natural products-from chemical properties to pharmacological activities. J. Med. Chem. 65(6), 4436–4456 (2022).Medline CASGoogle Scholar3. Wrobel JK, Power R, Toborek M. Biological activity of selenium: revisited. IUBMB Life 68(2), 97–105 (2016).Medline CASGoogle Scholar4. Leszczynska G, Cypryk M, Gostynski B et al. C5-substituted 2-selenouridines ensure efficient base pairing with guanosine; consequences for reading the NNG-3′ synonymous mRNA codons. Int. J. Mol. Sci. 21(8), 2882 (2020).Medline CASGoogle Scholar5. Hou W, Dong H, Zhang X, Wang Y, Su L, Xu H. Selenium as an emerging versatile player in heterocycles and natural products modification. Drug Discov. Today 27(8), 2268–2277 (2022).Medline CASGoogle Scholar6. Alhasan R, Nasim MJ, Jacob C, Gaucher C. Selenoneine: a unique reactive selenium species from the blood of tuna with implications for human diseases. Curr. Pharmacol. Reports. 5(3), 163–173 (2019).CASGoogle Scholar7. Feng X, Pan L, Qian Z et al. Discovery of selenium-containing STING agonists as orally available antitumor agents. J. Med. Chem. 65(22), 15048–15065 (2022).Medline CASGoogle Scholar8. Rech TDST, Ribeiro EH, Castro ET et al. Antidepressant potential of a functionalized 3-selanyl benzo[b]furan compound in mice: focus on the serotonergic system. ACS Chem. Neurosci. 14(6), 1181–1192 (2023).Medline CASGoogle Scholar9. Deng X, Xie B, Li Q et al. Discovery of novel bicyclic phenylselenyl-containing hybrids: an orally bioavailable, potential, and multiacting class of estrogen receptor modulators against endocrine-resistant breast cancer. J. Med. Chem. 65(11), 7993–8010 (2022).Medline CASGoogle Scholar10. Pyka P, Haberek W, Więcek M et al. First-in-class selenium-containing potent serotonin receptor 5-HT 6 agents with a beneficial neuroprotective profile against Alzheimer's disease. J. Med. Chem. 67(2), 1580–1610 (2024).Medline CASGoogle Scholar11. Bijian K, Wernic D, Nivedha AK et al. Novel aurora A and protein kinase C (α, β1, β2 and θ) multitarget inhibitors: impact of selenium atoms on the potency and selectivity. J. Med. Chem. 65(4), 3134–3150 (2022).Medline CASGoogle Scholar12. Kayrouz CM, Huang J, Hauser N, Seyedsayamdost MR. Biosynthesis of selenium-containing small molecules in diverse microorganisms. Nature 610(7930), 199–204 (2022).Medline CASGoogle Scholar13. Beletskaya IP, Ananikov VP. Transition-metal-catalyzed C–S, C–Se and C–Te bond formations via cross-coupling and atom-economic addition reactions. achievements and challenges. Chem. Rev. 122(21), 16110–16293 (2022).Medline CASGoogle Scholar14. Zhang X, Cheng F, Guo J, Zheng S, Wang X, Li S. Enzymatic synthesis of organoselenium compounds via C-Se bond formation mediated by sulfur carrier proteins. Nat. Synth. doi: 10.1038/s44160-023-00477-2 (2024) (Online).Google Scholar15. Hou W, Dong H, Yao Y et al. Clickable selenylation - a paradigm for seleno-medicinal chemistry. ChemMedChem. 17(17), e202200324 (2022).Medline CASGoogle Scholar16. Amporndanai K, Meng X, Shang W et al. Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. Nat. Commun. 12(1), 3061 (2021).Medline CASGoogle Scholar17. Xu H, Gu Y, Zhang S et al. A chemistry for incorporation of selenium into DNA-encoded libraries. Angew. Chem. Int. Ed. 59(32), 13273–13280 (2020).Medline CASGoogle Scholar18. Xu H, Wang Y, Dong H et al. Selenylation chemistry suitable for on-plate parallel and on-DNA library synthesis enabling high-throughput medicinal chemistry. Angew. Chem. Int. Ed. 61(35), e202206516 (2022).Medline CASGoogle Scholar19. Zhou Z, Gu Y, Wu L et al. Organo-Se BTSAs-enabled performance: from racemic and asymmetric synthesis to click chemistry application. Chem. 9(11), 3335–3346 (2023).CASGoogle Scholar20. Brenner S, Lerner RA. Encoded combinatorial chemistry. Proc. Natl Acad. Sci. USA 89(12), 5381–5383 (1992).Medline CASGoogle Scholar21. Ma P, Zhang S, Huang Q et al. Evolution of chemistry and selection technology for DNA-encoded library. Acta Pharm. Sin. B. 14(2), 492–516 (2024).Medline CASGoogle ScholarFiguresReferencesRelatedDetails Vol. 16, No. 6 STAY CONNECTED Metrics Downloaded 57 times History Received 5 February 2024 Accepted 6 February 2024 Published online 20 February 2024 Published in print March 2024 Information© 2024 Expert Publishing Science Ltd trading as Taylor & FrancisKeywordsbiocompatibleDNA-encoded libraryparallel synthesisseleniumAuthor contributionsW Hou and L Cui wrote the draft manuscript. HT Xu and W Hou revised the draft. HT Xu on behalf of all authors, submitted this manuscript. All authors have approved the submission of the manuscript.Financial disclosureThis work was supported by the Natural Science Foundation of China (numbers 21977070, 21907085 and U19A2011) and Fundamental Research Funds for the Provincial Universities of Zhejiang, China (No. RFA2022008). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Competing interests disclosureThe authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.Writing disclosureNo writing assistance was utilized in the production of this manuscript.PDF download
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
Ava应助瞿寒采纳,获得30
2秒前
动漫大师发布了新的文献求助10
3秒前
3秒前
晨曦完成签到,获得积分10
4秒前
李富贵完成签到,获得积分20
4秒前
听雪完成签到 ,获得积分10
6秒前
elias发布了新的文献求助10
7秒前
无花果应助云澈采纳,获得10
8秒前
今后应助蛋挞采纳,获得10
8秒前
小酸奶应助晨曦采纳,获得10
8秒前
善学以致用应助藿藿采纳,获得10
8秒前
CipherSage应助从容的皮卡丘采纳,获得10
9秒前
猫抓板发布了新的文献求助10
9秒前
852应助星辰采纳,获得10
11秒前
xiaofenzi完成签到 ,获得积分10
11秒前
初柒完成签到,获得积分20
12秒前
liukang172完成签到,获得积分10
12秒前
bingchem完成签到,获得积分10
12秒前
demoliu发布了新的文献求助10
12秒前
12秒前
肥羊七号完成签到 ,获得积分10
15秒前
15秒前
16秒前
16秒前
夜夜完成签到,获得积分10
16秒前
16秒前
Cactus应助liukang172采纳,获得10
17秒前
NexusExplorer应助吼吼哈哈采纳,获得10
17秒前
乐乐应助Raiden采纳,获得20
17秒前
17秒前
轻松绿旋发布了新的文献求助10
18秒前
hzd_23发布了新的文献求助10
19秒前
完美问玉完成签到,获得积分10
19秒前
乙醇完成签到 ,获得积分10
20秒前
云澈发布了新的文献求助10
21秒前
hdisyd完成签到 ,获得积分10
21秒前
蛋挞完成签到,获得积分10
22秒前
Keyl发布了新的文献求助50
22秒前
23秒前
高分求助中
All the Birds of the World 4000
Production Logging: Theoretical and Interpretive Elements 3000
Animal Physiology 2000
Les Mantodea de Guyane Insecta, Polyneoptera 2000
Am Rande der Geschichte : mein Leben in China / Ruth Weiss 1500
CENTRAL BOOKS: A BRIEF HISTORY 1939 TO 1999 by Dave Cope 1000
Machine Learning Methods in Geoscience 1000
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3740949
求助须知:如何正确求助?哪些是违规求助? 3283763
关于积分的说明 10036623
捐赠科研通 3000513
什么是DOI,文献DOI怎么找? 1646539
邀请新用户注册赠送积分活动 783771
科研通“疑难数据库(出版商)”最低求助积分说明 750427