Visible-Light-Driven Regioselective Decarboxylative Acylation of N-Methyl-3-phenylquinoxalin-2(1H)-one by Dual Palladium–Photoredox Catalysis Through C–H Activation

We report herein an efficient visible-light-promoted approach for the regioselective decarboxylative C–H acylation of N-methyl-3-phenylquinoxalin-2(1H)-ones using α-oxo-2-phenylacetic acids via dual palladium–photoredox catalysis. The reactions were carried out at room temperature in the presence of 24 W blue LEDs. The established protocol tolerated a wide range of functional groups and enabled the synthesis of several acylated N-methyl-3-phenylquinoxalin-2(1H)-ones in good to excellent yields. The proposed mechanism for this transformation was supported by control experiments.