纳米凝胶
明胶
化学
膜
生物物理学
癌细胞
细胞
细胞膜
纳米技术
癌症
细胞生物学
生物化学
材料科学
生物
药物输送
内科学
医学
有机化学
作者
Yuanzheng Wang,Chen Zhang,Shuyan Han,Xiaoli Kong,Changyun Quan,Jun Wu,Wei Zhang
标识
DOI:10.1016/j.cclet.2024.109578
摘要
Enhancing the active tumor targeting ability and decreasing the clearance of reticuloendothelial system (RES) are important issues for drug delivery systems (DDSs) in cancer therapy. In recent years, cell membrane camouflage, as one of the biomimetic modification strategies, has shown huge potential. Many natural properties of source cells can be inherited, allowing the DDSs to successfully avoid phagocytosis by macrophages, prolong circulation time, and achieve homologous targeting to lesion tissue. In this study, a cancer cell membrane camouflaged nanoplatform based on gelatin with a typical core-shell structure was developed for cancer chemotherapy. Doxorubicin (DOX) loaded gelatin nanogel (NG@DOX) acted as the inner core, and 4T1 (mouse breast carcinoma cell) membrane was set as the outer shell (M-NG@DOX). The M-NG platform enhanced the ability of homologous targeting due to the surface protein of cell membrane being completely retained, which could promote the cell uptake of homotypic cells, avoid phagocytosis by RAW264.7 macrophages, and therefore increase accumulation in tumor tissue. Meanwhile, due to the better controlled drug release capability of M-NG@DOX, premature release of DOX in circulation could be reduced, minimizing side effects in common chemotherapy. As a result, the biomimetic nanoplatform in this study, obtained by a cancer cell membrane camouflaged drug delivery system, efficiently reached desirable tumor elimination, providing a significant strategy for effective targeted therapy and specific carcinoma therapy.
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