甲壳素
自愈水凝胶
伤口敷料
纳米纤维
脚手架
生物相容性
3D打印
纳米技术
高分子化学
化学
壳聚糖
纳米纤维素
组织工程
化学工程
材料科学
生物医学工程
复合材料
纤维素
工程类
医学
冶金
作者
Yiran Zheng,Hao Zhang,Zhiwei Wang,Ang Lu,Aixi Yu,Bo Duan
标识
DOI:10.1016/j.carbpol.2024.122028
摘要
The direct ink writing technique used in 3D printing technology is generally applied to designing biomedical hydrogels. Herein, we proposed a strategy for preparing all-chitin-based inks for wound dressing via direct ink writing technique. The β-chitin nanofibers (MACNF) with a high aspect ratio were applied as a nanofiller to modulate the rheological properties of the alkaline dissolved chitin solution. The printing fidelity significantly depends on the MACNF introduction amount to the composite ink. 5–10 wt% MACNF ratio showed superior printing performance. The printed scaffold showed a uniform micron-sized pore structure and a woven network of nanofibers. Due to the good biocompatibility of chitin and the stereoscopic spatial skeleton, this scaffold showed excellent performance as a wound dressing, which can promote cell proliferation, collagen deposition and the angiogenesis of wounds, demonstrating its potential in biomedical applications. This approach successfully balanced the chitinous printability and biofunctions.
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