癌症研究
基因沉默
膀胱癌
恶性肿瘤
转移
小RNA
细胞生长
体内
细胞培养
癌症
基因敲除
生物标志物
细胞周期
化学
生物
医学
病理
内科学
基因
生物化学
遗传学
生物技术
作者
Jiahe Yi,Xueyou Ma,Yufan Ying,Zingcheng Liu,Yanbin Tang,Xuan Shu,Jiazhu Sun,Yuqing Wu,Dingheng Lu,Xiao Wang,Jindan Luo,Ben Liu,Xiangyi Zheng,Yiwei Lin,Jiangfeng Li,Liping Xie
标识
DOI:10.1016/j.canlet.2024.216613
摘要
Several studies have indicated that circular RNAs (circRNAs) play vital roles in the progression of various diseases, including bladder cancer (BCa). However, the underlying mechanisms by which circRNAs drive BCa malignancy remain unclear. In this study, we identified a novel circRNA, circPSMA7 (circbaseID:has_circ_0003456), showing increased expression in BCa cell lines and tissues, by integrating the reported information with circRNA-seq and qRT-PCR. We revealed that circPSMA7 is associated with a higher tumor grade and stage in BCa. M6A modification was identified in circPSMA7, and IGF2BP3 recognized this modification and stabilized circPSMA7, subsequently increasing the circPSMA7 expression. In vitro and in vivo experiments showed that circPSMA7 promoted BCa proliferation and metastasis by regulating the cell cycle and EMT processes. CircPSMA7 acted as a sponge for miR-128-3p, which showed antitumor effects in BCa cell lines, increasing the expression of MAPK1. The tumor proliferation and metastasis suppression induced by silencing circPSMA7 could be partly reversed by miR-128-3p inhibition. Thus, the METTL3/IGF2BP3/circPSMA7/miR-128-3p/MAPK1 axis plays a critical role in BCa progression. Furthermore, circPSMA7 may be a potential diagnostic biomarker and novel therapeutic target for patients with BCa.
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