[A Case of Breast Carcinoma That Changed Subtype to Squamous Cell Carcinoma after Chemotherapy].

医学 多西紫杉醇 转移 三苯氧胺 乳腺癌 肿瘤科 内科学 癌症
作者
Kazuya Konishi,Jun Araya,Makoto Nagabuchi,Takashi Sakamoto,Jiro Ogino,Satoshi Hirano
出处
期刊:PubMed 卷期号:50 (7): 825-827
链接
标识
摘要

Metaplastic carcinoma is a rare histological malignancy, often triple-negative, and has a poor prognosis. Here, we report a case of breast cancer in which the primary lesion degenerated into squamous cell carcinoma(triple negative)after drug treatment for invasive ductal carcinoma(Luminal type). The patient was a 41-year-old woman who was diagnosed with Stage Ⅳ left breast cancer T2N2bM1(HEP)(ER 90%, PR 70%, HER2 2+, FISH-)at another hospital and participated in the PATHWAY study(tamoxifen plus goserelin plus palbociclib/placebo). Since the primary lesion and liver metastasis increased in size, the study was discontinued after 8 weeks. She was treated at our hospital thereafter, with capecitabine plus cyclophosphamide, palbociclib plus fulvestrant plus leuprorelin, paclitaxel plus bevacizumab, eribulin, EC therapy, and docetaxel. However, both the primary lesion and liver metastasis increased. In particular, the increase in primary lesion size was remarkable, and the QOL significantly reduced due to bleeding and exudation. Biopsy performed during docetaxel treatment revealed metaplastic/squamous cell carcinoma(ER-, PR-, HER2 0, Ki-67 90-100%)histopathological findings. BRCA and microsatellite instability tests were negative, and PDL1 expression was less than 1%. Although Mohs ointment was used, tumor bleeding, exudate, and stink were poorly controlled, and the patient experienced painful symptoms due to the weight of the tumor. Therefore, left mastectomy plus pectoralis major muscle resection was performed. The patient died one month after the operation.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
weiwei1996完成签到,获得积分20
1秒前
小小li完成签到 ,获得积分10
1秒前
2秒前
怕黑笑蓝完成签到,获得积分10
2秒前
小果子完成签到 ,获得积分10
2秒前
哈哈哈发布了新的文献求助10
2秒前
搜集达人应助张达采纳,获得10
3秒前
陈越越越发布了新的文献求助10
3秒前
4秒前
图灵桑发布了新的文献求助10
4秒前
WL关闭了WL文献求助
4秒前
英姑应助科研啊科研采纳,获得10
4秒前
米恩完成签到,获得积分10
5秒前
5秒前
xcn发布了新的文献求助10
6秒前
爆米花应助科研通管家采纳,获得30
6秒前
星辰大海应助科研通管家采纳,获得10
6秒前
科研通AI5应助科研通管家采纳,获得10
6秒前
天天快乐应助科研通管家采纳,获得10
6秒前
香蕉觅云应助科研通管家采纳,获得10
6秒前
汉堡包应助科研通管家采纳,获得10
6秒前
所所应助科研通管家采纳,获得10
6秒前
科研通AI2S应助科研通管家采纳,获得10
6秒前
6秒前
6秒前
7秒前
就是笨怎么了完成签到 ,获得积分10
7秒前
Archer发布了新的文献求助10
8秒前
Miao完成签到,获得积分10
8秒前
tong发布了新的文献求助10
9秒前
9秒前
大意的友儿完成签到,获得积分10
10秒前
10秒前
12秒前
13秒前
13秒前
14秒前
14秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3542648
求助须知:如何正确求助?哪些是违规求助? 3120011
关于积分的说明 9341267
捐赠科研通 2818101
什么是DOI,文献DOI怎么找? 1549346
邀请新用户注册赠送积分活动 722106
科研通“疑难数据库(出版商)”最低求助积分说明 712944