NAD+激酶
ADP核糖基化
聚ADP核糖聚合酶
核糖
基质（水族馆）
化学
生物化学
聚合酶
立体化学
酶
组合化学
生物
生态学
作者
Elisa Stephens,Xiao‐Nan Zhang,Albert T. Lam,Jiawei Li,Hua Peng,Stan G. Louie,Clay C. C. Wang,Yong Zhang
摘要
An NAD+ featuring an adenosyl 4'-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD+ with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.
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