Isoxerophilins A and B, two diterpene heterodimers from Isodon xerophilus: structural elucidation and semisynthesis of isoxerophilin analogues
半合成
二萜
化学
立体化学
作者
Jia-Meng Dai,Bing‐Chao Yan,Lingmei Kong,Kun Hu,Xing-Ren Li,Xiaonian Li,Han‐Dong Sun,Yan Li,Pema‐Tenzin Puno
出处
期刊:Organic chemistry frontiers [The Royal Society of Chemistry] 日期:2024-01-01卷期号:11 (1): 37-46
标识
DOI:10.1039/d3qo01679j
摘要
Two unprecedented diterpene heterodimers, isoxerophilins A and B (1 and 2), were isolated from Isodon xerophilus . A bioinspired semisynthesis of ten isoxerophilin analogues was accomplished. Compound 12 exhibited obvious latent tumor immunotherapy activity.