伤口愈合
自愈水凝胶
氧气
缺氧(环境)
慢性伤口
血管生成
过氧化氢
氧气疗法
化学
医学
外科
麻醉
癌症研究
生物化学
有机化学
作者
Zhixuan Yang,Kaixuan Ren,Yehao Chen,Xinyan Quanji,Chengfeng Cai,Jingbo Yin
标识
DOI:10.1002/adhm.202302391
摘要
Abstract Hypoxia in chronic wounds impairs the activities of reparative cells, resulting in tissue necrosis, bacterial infections, decreased angiogenesis, and delayed wound healing. To achieve effective oxygenation therapy and restore oxygen homeostasis, oxygen‐generating hydrogels based on different oxygen sources have been developed to release dissolved oxygen in the wound bed, which not only alleviate hypoxia, but also accelerate chronic wound healing. This review first discusses the vital role of oxygen and hypoxia in the wound healing process. The advancements in oxygen‐generating hydrogels, which produce oxygen through the decomposition of hydrogen peroxide, metal peroxides, glucose‐activated cascade reactions, and photosynthesis of algae microorganisms for chronic wound healing, are discussed and summarized. The therapeutic effects and challenges of using oxygen‐generating hydrogels for the clinical treatment of chronic wounds are concluded and prospected.
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