Effects of a Single Session of OnabotulinumtoxinA Therapy on Sleep Quality and Psychological Measures: Preliminary Findings in a Population of Chronic Migraineurs

匹兹堡睡眠质量指数 贝克抑郁量表 贝克焦虑量表 焦虑 医院焦虑抑郁量表 医学 萧条(经济学) 物理疗法 偏头痛 慢性偏头痛 人口 内科学 精神科 睡眠质量 失眠症 经济 宏观经济学 环境卫生
作者
Angelo Torrente,Paolo Alonge,Laura Pilati,Andrea Gagliardo,Lavinia Vassallo,Vincenzo Di Stefano,Antonino Lupica,Irene Quartana,Giovanna Viticchi,Mauro Silvestrini,Marco Bartolini,Cecilia Camarda,Filippo Brighina
出处
期刊:Toxins [Multidisciplinary Digital Publishing Institute]
卷期号:15 (9): 527-527
标识
DOI:10.3390/toxins15090527
摘要

Chronic migraine is a burdensome condition, and onabotulinumtoxinA is revealed to be an effective therapy. Migraine shows a bidirectional relationship with sleep, but the effects of preventive therapies on sleep quality are poorly studied. This study aims to evaluate the effects of a single session of onabotulinumtoxinA on patients’ sleep quality and correlates the results with measures of comorbid anxiety/depression. Patients completed self-administrable questionnaires about sleep quality (Pittsburgh Sleep Quality Index—PSQI) and psychological symptoms (Beck Depression Inventory, 2nd edition—BDI-II—and Hospital Anxiety and Depression Scale—HADS—subscales “a” and “d” for anxiety and depression, respectively), and reported migraine frequency at baseline and after 12 weeks. The 42 included patients showed a significant reduction in migraine days (from 20.6 ± 6.0 to 13.6 ± 6.2, p < 0.001), while no changes were observed in sleep quality (PSQI score from 11.0 ± 5.0 to 9.8 ± 4.6, p = 0.277) or psychological measures (BDI-II from 16.7 ± 10.2 to 15.7 ± 10.3, p = 0.678; HADS-a from 10.3 ± 4.8 to 9.3 ± 5.5, p = 0.492; and HADS-d from 7.2 ± 3.9 to 7.1 ± 5.0, p = 0.901). On the other hand, a strong correlation among PSQI, BDI-II, HADS-a, and HADS-d scores (p < 0.001, rho > 0.7) was found. Despite its efficacy in migraine prevention, a single session of onabotulinumtoxinA was not able to affect patients’ sleep quality or their psychological symptoms.

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